F-amidine warning this product is for research use only, not for human or veterinary use. Medkoo cat 56 description f-amidine is a bioavailable irreversible inactivator of pad4. Price and availability size price shipping out time quantity inquire bulk and customized quantity add to cart pricing updated .
F-amidine (trifluoroacetate salt) is an irreversible inhibitor of protein arginine deiminase (pad).
F Amidine (trifluoroacetate salt) BioVision
F-amidine (trifluoroacetate salt) is an irreversible inhibitor of protein arginine deiminase (pad). The ic for cytoxicity in hl-60, mcf-7, and ht-29 cancer cell lines is 0.
F-amidine is an inhibitor of protein arginine deiminases (pads) that is selective for pad1 and pad4 (ic 50 s 29. 1,2 it irreversibly inactivates all four pad subtypes (k inact k i 2,800, 380, 170, and 3,000 m-1 min-1 by covalently modifying an active site cysteine that is important for its catalytic activity.).
The bioavailability of this compound suggests that f-amidine will be a powerful chemical probe of pad4 function that can be used to dissect the roles of this enzyme in both rheumatoid arthritis and transcriptional control. The fact that inhibition is of an irreversible nature suggests that, with appropriate functionalization, f-amidine analogues will be robust activity-based protein-profiling.
O-f-amidine c17h20f4n4o6938 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities.
F Amidine | CAS 877617 45 3 | SCBT Santa Cruz Biotechnolog
F-amidine is an inhibitor of peptidyl arginine deiminase 4 (pad4) activity with an ic50 value of 21. It irreversibly inactivates (kinactki 3,000 m-1min-1) pad4 by covalently modifying an active site cysteine that is important for its catalytic activity.